Betty, an aspiring actress, comes to Los Angeles on vacation and finds a mysterious dark-haired woman hiding in her relatives' house, with amnesia after a car accident on Mulholland Road. Beti decides to help a woman named Rita, and the two of them embark on a psychotic, delusional search for Rita's past and identity, which intertwines with the story of another hero - a film director looking for an actress for the lead role. In this multi-layered, dreamy neo noir thriller that has been the subject of endless debate since its release, the director turns the notions of reality and identity upside down.